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Axure RP Pro is an excellent rapid prototyping software to create interactive wireframe, HTML prototype, mockup, etc.
Axure RP Pro has box, placeholder, shape, and text tool to create prototype quickly. Using the Event and Case to add action to the wireframe to make it interactive, there are OnClick/OnMouseEnter/OnKeyUp events, and Open Link/Set Widget Value/Show Panel actions.
Then you can generate an interactive HTML website wireframe or UI mockup without coding.